Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism
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چکیده
منابع مشابه
Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes.
Recent data suggest that beta-adrenergic receptor subtypes couple differentially to signaling pathways regulating cardiac function vs. cardiac remodeling. To dissect the roles of beta1- vs. beta2-receptors in the pathogenesis of cardiomyopathy, doxorubicin was administered to beta1, beta2, and beta1/beta2 knockout (-/-) and wild-type mice. Expression and activation of MAPKs were measured. Wild-...
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The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
متن کاملImpaired Beta Adrenergic Receptor
Address reprint requests to Dr. Galant, Memorial Hospital Medical Center of Long Beach, Calif. Received for publication 12 August 1980 and in revised form 23 March 1981. group to include agonist binding, receptor-adenylate cyclase coupling, intrinsic adenylate cyclase activity, and catecholamine metabolism may help determine the basic cause of beta adrenergic hyporesponsiveness in both CFH and CF.
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Adrenergic beta-blocking agents were given to 7 patients with advanced congestive cardiomyopathy who had tachycardia at rest (98 plus or minus 13 beats/min). The patients were on beta-adrenergic receptor blockade for 2 to 12 months (average 5-4 months). One patient was given alprenolol 50 mg twice daily and the other patients were given practolol 50 to 400 mg twice daily. Virus infection had oc...
متن کاملDifferential cardioprotective/cardiotoxic effects mediated by !-adrenergic receptor subtypes
Bernstein, Daniel, Giovanni Fajardo, Mingming Zhao, Takashi Urashima, Jennifer Powers, Gerald Berry, and Brian K. Kobilka. Differential cardioprotective/cardiotoxic effects mediated by !-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol 289: H2441–H2449, 2005. First published July 22, 2005; doi:10.1152/ajpheart.00005.2005.—Recent data suggest that !-adrenergic receptor subtypes coup...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2012
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2011.12.046